MRI related research

The MRI Group focuses on using Magnetic Resonance Imaging (MRI) to diagnose, understand, and evaluate treatments of central nervous system disorders. We do this through a better understanding of how MRI metrics correlate with anatomy and function.


The research in this lab is performed in 2 centres

1. In Vivo Experimental Animal Magnetic Resonance Micrscopy Centre located at the Health Sciences Centre.

Pictured at right is the Martin MRI Group near a 7 T Horizontal Bore Bruker MR scanner which is located at HSC.


2. The University of Winnipeg  MRI Laboratory

Pictured at right is the Martin MRI Group in the MRI Laboratory located at the University of Winnipeg.



Recent publications from the lab


Hayes K, Buist R, Vincent TJ, Thiessen JD, Zhang Y, Zhang H, Wang J, Summers AR, Kong J, Li XM, Martin M, Comparison of Manual and Semiautomated Segmentation Methods to Evaluate Hippocampus Volume in APP and PS1 Transgenic Mice obtained via in-vivo Magnetic Resonance Imaging, Journal of Neuroscience Methods, in press.


Kastyak-Ibrahim MZ, Di Curzio DL, Buist R, Herrera SL, Albensi BC, Del Bigio MR, Martin M, Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice, Magnetic Resonance Imaging, 31 (2013) 1515-1521.


Thiessen JD, Zhang Y, Zhang H, Wang L, Buist R, Del Bigio MR, Kong J, Li, XM, Martin M. Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination, NMR in Biomedicine 2013, 26; 1562-1581.


Martin M, Measuring Restriction Sizes Using Diffusion Weighted Magnetic Resonance Imaging: A Review. Magnetic Resonance Insights, 2013:6 59-64.


Thiessen JD, Vincent TJ, Herrera SL, Martin M, Diffusion Tensor Metric Measurements as a Function of Diffusion-Time in Rat Central Nervous System, Magnetic Resonance Insights, 2012:5 37-47.


Soylu H, Zhang D, Buist R, Martin M, Albensi BC, Parkinson FE, Intracortical injection of endothelin-1 induces cortical infarcts in mice:  effect of neuronal expression of an adenosine transporter, Experimental & Translational Stroke Medicine, 2012, 4:4.


Vincent TJ, Thiessen JD, Kurjewicz LM, Germscheid SL, Turner AJ, Zhilkin P, Alexander ME, Martin M, Longitudinal Brain Size Measurements in APP/PS1 Transgenic Mice, Magnetic Resonance Insights, 2010:4 1926.


Thiessen JD, Glazner KAC, Nafez S, Schellenberg AE, Buist R, Martin M, and Albensi BC. Histochemical visualization and diffusion MRI at 7 Tesla in the TgCRND8 transgenic model of Alzheimer's disease. Brain Structure and Function (2010), 215:29-36.


Odero GL, Oikawa K, Glazner KAC, Grossman D, Thiessen JD, Motnenko A, Ge N, Martin M, Glazner GW, Schapansky J, Albensi BC. Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease. Neuroscience 169 (2010), 532-543.


MacKenzie-Graham A, Tiwari-Woodruff SK, Sharma G, Aguilar C, Vo KT, Strickland LV, Morales L, Fubara B, Martin M, Jacobs RE, Johnson GA, Toga AW, Voskuhl RR, Purkinje cell loss in experimental autoimmune encephalomyelitis, Neuroimage 48 (2009), 637-651.